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KMID : 0882420100780020226
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Korean Journal of Medicine
2010 Volume.78 No. 2 p.226 ~ p.230
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Autoimmune hemolytic anemia during PEG-interferon and ribavirin treatment for hepatitis C
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Yoo Ji-Yeon
Jang Jeong-Won
Kim Chang-Wook
Yoon Seung-Gyu
Kim Jin-Dong
Kwon Jung-Hyun
Lee Chang-Don
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Abstract
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The current best treatment for HCV infection is combination therapy with PEG-interferon and ribavirin. This combination therapy has markedly increased the number of sustained virologic responders but is associated with various side effects, especially hematological abnormalities. We recently experienced a 45-year-old man who developed PEG-interferon induced autoimmune hemolytic anemia (AIHA) and retinal premacular hemorrhage. The worsening hemolysis after ribavirin withdrawal and exclusion of other causes implicated PEG-interferon as the cause of the AIHA. To the best of our knowledge, this is the first case reported from Korea. Treatment with PEG-interferon requires careful follow-up, as it can induce or exacerbate autoimmune diseases.
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KEYWORD
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Chronic hepatitis C, Autoimmune hemolytic anemia, Retinal hemorrhage, PEG-interferon
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